Monongalia County fire departments were called to the scene of a confirmed structure fire on Hornbeck Road that started around 5:30 p.m. Friday.
The Clinton District Volunteer Fire Department said the house is a total loss.
It believes the fire started in the rear bedroom, but the cause is unknown.
No one was home at the time of the fire, and there were no injuries reported.
Hornbeck Road was temporarily closed due to the fire.
Clinton District Volunteer Fire Department and the State Fire Marshal are investigating.
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