The Lumberport Fire Department responded to the scene of a fire on Gregory's Run Road just after 3:30 p.m. Wednesday.
Firefighters said the fire started in the kitchen of the house and that no one was home at the time.
Smoke damaged the rest of the home and it is a total loss, according to officials.
It took firefighters about 15 minutes to get the fire under control.
The Shinnston Fire Department, Wallace Fire Department and Harrison County EMS also responded to the scene.