The Harrison County Sheriff's Department said two people were sent to the hospital after an early Sunday morning accident.
It happened just after 10 a.m. on Route 19 near Skyline Hill.
Sheriff deputies said a woman driving a 2003 Hyundai Sonata crossed the center line and struck a 2011 Ford 350 head on.
The woman was flown by helicopter to Ruby Memorial Hospital.
A male passenger in the pickup was transported to United Hospital Center. The driver of that pickup wasn't injured.
No further information is being released at this time.
The accident is still under investigation.